You must submit full information on all of the components of your product (solvent) – including all CAS registry numbers for chemicals intentionally added or present at > 0.01% by mass – to NSF International for third-party review. Criteria for non-solvent ingredients such as denaturants and unexpected residuals that may be present in individual lots should be listed even though a de minimis has yet to be determined.
You may confidentially provide NSF with internal test data for Tier 1 attributes, which, for solvents, include: acute aquatic toxicity, acute mammalian toxicity, bioconcentration factor, carcinogenicity, developmental toxicity, fate and ecotoxicity, neurotoxicity, repeated exposure systemic toxicity, and reproductive toxicity.
In order to be listed in CleanGredients®, all solvents must pass a minimal set of requirements for fate, human health and environmental toxicity. The Solvents TAC recommended adoption of the Phase 1 DfE Solvent Screen as the CleanGredients solvents listing criteria. The criteria are summarized in the table below; the full document should be reviewed before applying the screen. Phase 1 comprises alcohols, esters, ethylene glycol ethers, and propylene glycol ethers. At this time, only solvents in these four classes may be listed in CleanGredients. DfE is working on Phase 2 of their solvent screen, which we expect to include terpenes, amines, and amides. The CleanGredients Solvents TAC has requested that DfE also consider including hydrocarbons in Phase 2.
| Attribute | A solvent can be listed in CleanGredients if... | ||
|---|---|---|---|
| Acute Mammalian Toxicity | Its acute mammalian toxicity testing falls within
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| Carcinogenicity | It is not included on the following lists:
NTP:
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| Developmental Toxicity | Its developmental toxicity effect level is
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| Environmental Fate and Toxicity (PBT status) | Acute Aquatic Toxicity Value (L/E/IC50 ) | Persistence (Measured in terms of rate of biodegredation) | Bioaccumulation Potential |
| If ≤ 1 ppm... | ...then may be acceptable if biodegradation occurs within 10-day window... | ...and BCF <1000 | |
| If > 1 ppm and ≤ 10 ppm... | ...then biodegradation must occur within a 10-day window... | ...and BCF <1000 | |
| If > 10 ppm and < 100 ppm... | ...then biodegradation must occur within 28 days without degradation products of concern... | ...and BCF <1000 | If ≥ 100 ppm... | ...then biodegradation need not occur within 28 days if there are no degradation products of concern and half-life < 180 days... | ...and BCF <1000 |
| Neurotoxicity | It does not require a GHS categorization of 1 or 2.
Its neurotoxicity effect level is
The GHS criteria and data evaluation approach and EPA risk assessment guidance will inform professional judgment in the review of both NOAEL/NOAEC and LOAEL/LOAEC values. |
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| Repeated Exposure Systemic Toxicity | It does not require a GHS categorization of 1 or 2.
Its repeated exposure systemic toxicity effect level is
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| Reproductive Toxicity | Its reproductive toxicity effect level is
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Whenever feasible, use the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). See each attribute page for more information on the reporting format for that specific value.
If you have any questions, please contact us.
