Acute Mammalian Toxicity - Master in Solvents
Definition
1. Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalation exposure of 4 hours.
2. The degree to which a substance or mixture of substances can cause harmful effects in an animal of the kingdom Mammalia through a single or short-term exposure.
Rationale
Mammalian toxicity is a form of inherent hazard. A primary objective of the CleanGredients® database is to provide guidance for choosing chemicals that are inherently less dangerous than conventional options. Products formulated with safer chemicals have lower risk associated with accidents or exposure across the product lifecycle.
Listing Requirements
As a prerequisite for being listed in CleanGredients, all solvents must have their acute mammalian toxicity data evaluated by a third party.
Solvents listed in CleanGredients® must have developmental toxicity test results of at least (using the most sensitive methodology):
- Acute Oral LD50 > 2000 mg/kg/day
- Acute Dermal LD50 > 2000 mg/kg/day
- Acute Inhalation (Gas) LC50 > 5000 ppm/4hr (Vapor) LC50 > 20 mg/L (Dust/Mist) LC50 > 5 mg/L
Data and Submission Guidance
The preferred acute mammalian toxicity test methods include:
- Acute Oral: OECD Test No. 425
- Acute Dermal: OECD Test No. 402
- Acute Inhalation: OECD Test No. 403 Other similar or relevant test methods will be accepted. Please submit data for the following three endpoints:
- Oral LD50, mg/kg of body weight
- Dermal LD50, mg/kg of body weight
- Inhalation LC50, ppm/volume/time for gases, mg/L/time for vapors, mg/L/time for dusts and mists Answers may be in the form of ranges (i.e. >2000). Please specify the species, test method, and testing conditions in the text box provided.