Acute Aquatic Toxicity - Master in Solvents
Definition
The intrinsic property of a substance to be injurious to an aquatic organism in a short-term exposure to that substance.
Rationale
Aquatic toxicity is a form of inherent hazard. A primary objective of the CleanGredients® database is to provide guidance for choosing chemicals that are inherently less hazardous than conventional options. Products formulated with safer chemicals have lower risk associated with accidents or exposure across the product lifecycle.
Listing Requirements
- If (L/E/IC50) ≤ 1 ppm, then may be acceptable if biodegradation occurs within a 10-day window and BCF < 1000.
- If (L/E/IC50) > 1 ppm and ≤ 10 ppm, then biodegradation must occur within a 10-day window and BCF < 1000.
- If (L/E/IC50) > 10 ppm and < 100 ppm, then biodegradation must occur within 28 days without products of concern and BCF < 1000.
- If (L/E/IC50) ≥ 100 ppm, then biodegradation need not occur within 28 days if there are no products of concern and half-life < 180 days and BCF < 1000.
Data and Submission Guidance
Substances that result in acute aquatic toxicity are assigned to one of three toxicity categories: LC50 (fish) or EC50 (crustacea, i.e. daphnia) or ErC50 (for algae or other aquatic plants).
The preferred acute aquatic toxicity test methods are:
- OECD Test No. 203, Fish, Acute Toxicity Test; [OPPTS 850.1075]
- OECD Test No. 201, Algae, Acute Toxicity Test; [OPPTS 850.5400]
- OECD Test No. 202, Daphnia, Acute Toxicity Test; [OPPTS 850.1010] Other similar or relevant test methods will be accepted, including data from older ISO, CFR, and ASTM tests. Though test data is preferred, modeled data (i.e. using the PBT profiler) is acceptable. Please include the following endpoints:
- Fish (LC50)
- Daphnia (EC50)
- Algae (ErC50) For each entry include the species, the duration of exposure, and the test method (enter in the appropriate text boxes).