Repeated Exposure Systemic Toxicity in Solvents
Rationale
Repeated exposure systemic toxicity is a form of inherent hazard. A primary objective of the CleanGredients® database is to provide guidance for choosing chemicals that are inherently less dangerous and don’t require as many handling precautions as conventional options. Products formulated with safer chemicals will have lower risk associated with accidents or exposure across the product lifecycle.
Listing Requirements
As a prerequisite for being listed in CleanGredients, all solvents must have their repeated exposure systemic toxicity data evaluated by a third party.
Solvents listed in CleanGredients cannot require a GHS categorization of 1 or 2 and must have repeated exposure systemic toxicity test results of at least:
- Oral 90-day LOEL/LOAEL > 100 mg/kg-bw/day
- Dermal 90-day LOEL/LOAEL >200mg/kg-bw/day
- Inhalation (Gas) 90-day LOEL/LOAEL >250ppm/6hr/day (Vapor) 90-day LOEL/LOAEL >1.0mg/L/6hr/day (Dust/Mist/Fumes) 90-day LOEL/LOAEL >0.2mg/L/6hr/day